A genome-wide scan for naevus count: linkage to CDKN2A and to other chromosome regions
نویسندگان
چکیده
منابع مشابه
A genome-wide scan for linkage to human exceptional longevity identifies a locus on chromosome 4.
Substantial evidence supports the familial aggregation of exceptional longevity. The existence of rare families demonstrating clustering for this phenotype suggests that a genetic etiology may be an important component. Previous attempts at localizing loci predisposing for exceptional longevity have been limited to association studies of candidate gene polymorphisms. In this study, a genome-wid...
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BACKGROUND & OBJECTIVES Essential hypertension is a multifactorial disorder with a complex phenotype. Here we report a susceptibility locus for the hypertension mapped by a genome-wide microsatellite scanning in an affected Chinese family, in which 11 members had hypertension before the age of 40. METHODS A total of 22 individuals from a single family from Shanghai, PR China, were genotyped o...
متن کاملGenome-wide scan for premature hypertension supports linkage to chromosome 2 in a large Kyrgyz family.
We report a genome-wide scan for susceptibility loci to hypertension in a single Kyrgyz family where 10 of the affected relatives developed hypertension before the age of 35 years, and some members have suffered stroke. The early onset of disease and the geographic isolation of the Kyrgyz population are both expected to select for an increased influence of genetic factors in hypertension. We ge...
متن کاملGenome-wide scan for prospective memory suggests linkage to chromosome 12q22.
Prospective memory slips (forgetting to do something) are as part of everyday memory failure as retrospective complaints (forgetting a past event). The extent to which genes influence prospective and retrospective memory is so far unclear. This study aims to quantify the relative genetic and environmental influences on such memory slips and seeks to identify QTL's with the first genome-wide sca...
متن کاملGenome-wide scan for Japanese familial intracranial aneurysms: linkage to several chromosomal regions.
BACKGROUND Genetic factors have an important role in the pathogenesis of intracranial aneurysm (IA). The results of previous studies have suggested several loci. METHODS AND RESULTS From 29 IA families with > or =3 individuals affected by IA, we used nonparametric (model-free) methods for linkage analyses, using GENEHUNTER and Merlin software. Genome-wide linkage analyses revealed 3 regions o...
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ژورنال
عنوان ژورنال: European Journal of Human Genetics
سال: 2006
ISSN: 1018-4813,1476-5438
DOI: 10.1038/sj.ejhg.5201729